HDAC6 Antibody, ALEXA FLUOR 594

Catalog numberbs-2811R-A594
NameHDAC6 Antibody, ALEXA FLUOR 594
Price€ 380.00
Size100ul
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Long nameHDAC6 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
Also known asAnti-HDAC6 PAb ALEXA FLUOR 594
CategoryConjugated Primary Antibodies
Conjugated withALEXA FLUOR® 594
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenHDAC6
SpecificityThis is a highly specific antibody against HDAC6.
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range330-380/1215
Subcellular locationCytoplasm, Nucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HDAC6
Gene ID Number10013
Swiss ProtQ9UBN7
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
CrossreactivityHuman, Mouse, Rat
Cross-reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigenResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
PurificationPurified by Protein A.
Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Excitation emission590nm/617nm
SynonymsHD6; JM21; CPBHM; PPP1R90; Histone deacetylase 6; HDAC6; KIAA0901
PropertiesFor facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
ConjugationAlexa Fluor,ALEXA FLUOR® 594
ConjugatedAlexa conjugate 1
French translationanticorps