presenilin 1 Antibody, ALEXA FLUOR 350

Catalog numberbs-0024R-A350
Namepresenilin 1 Antibody, ALEXA FLUOR 350
Price€ 380.00
Size100ul
  Get from shop
Long namepresenilin 1 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
Also known asAnti-presenilin 1 PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated withALEXA FLUOR® 350
Host OrganismRabbit (Oryctolagus cuniculus)
Target Antigenpresenilin 1
SpecificityThis is a highly specific antibody against presenilin 1.
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range1-50/467
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from mouse Presenilin-1 NTF subunit
Gene ID Number5663
Swiss ProtP49768
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
CrossreactivityHuman, Mouse, Rat
Cross-reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigenProbable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
PurificationPurified by Protein A.
Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Excitation emission343nm/442nm
SynonymsAD3; FAD; PS1; PS-1; S182; Presenilin-1; Protein S182; PSEN1; PSNL1
PropertiesFor facs or microscopy Alexa 1 conjugate.Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
ConjugationAlexa Fluor,ALEXA FLUOR 350
French translationanticorps