c-Met(Tyr1234 + Tyr1235) Antibody

Catalog numberbs-3272R
Namec-Met(Tyr1234 + Tyr1235) Antibody
Price€ 281.00
Size0.1ml
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Long namec-Met(Tyr1234 + Tyr1235) Antibody
Also known asc-Met(Tyr1234 + Tyr1235) Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target Antigenc-Met Tyr1234 + Tyr1235
SpecificityThis is a highly specific antibody against c-Met Tyr1234 + Tyr1235. These phosphorylation sites are homologous to Tyr1232 + Ty1233 in Mouse and Tyr1235 + Tyr1236 in Rat. Due to the highly conserved nature of this domain, there is a chance that this antibody will react with MSP receptors in Mouse and, less likely, in Human when phosphorylated at the the sites of Ser1238 and Ser1239 in Human, Ser1215 and Ser1216 in Mouse. No phosphorylation information is currently available Rat.
Modification(s)Phosphorylation
Modification site(s)Tyr1234 + Tyr1235
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range1220-1240/1390
Subcellular locationHelical
SourceKLH conjugated synthetic phosphopeptide derived from human c-Met around the phosphorylation site of Tyr1234/1235
Gene ID number4233
Swiss ProtP08581
Tested ApplicationsWB, IHC-P, IF(IHC-P)
Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Cross reactivityHuman, Mouse, Rat
Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the target antigenReceptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
Purification methodThis antibody was purified via Protein A.
Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Synonym namesHGFR; AUTS9; RCCP2; c-Met; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; MET
PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translationanticorps