TRAF2 (214CT16.3.4) Monoclonal Antibody

Catalog numberbsm-51060M
NameTRAF2 (214CT16.3.4) Monoclonal Antibody
Price€ 211.00
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Long nameTRAF2 (214CT16.3.4) Monoclonal Antibody
Also known asTRAF2 (214CT16.3.4) Monoclonal Antibody
CategoryPrimary Antibodies
Target AntigenTRAF2
SpecificityThis is a highly specific antibody against TRAF2.
Modification site(s)Unmodified antibody
Clone number214CT16.3.4
SourceThis TRAF2 monoclonal antibody is generated from mouse immunized with TRAF2 recombinant protein.
Gene ID number7186
Swiss ProtQ12933
Tested ApplicationsWB, IF
Recommended dilutionsWB(1:100-1000), IF(1:10~50)
Cross reactivityHuman
Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the target antigenRegulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
Purification methodPurified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Synonym namesTRAP; TRAP3; MGC:45012; TNF receptor-associated factor 2; E3 ubiquitin-protein ligase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3; TRAF2
PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
French translationanticorps