TP63 (603CT12.4.3) Monoclonal Antibody

Catalog numberbsm-51191M
NameTP63 (603CT12.4.3) Monoclonal Antibody
Price€ 328.00
Size0.1ml
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Long nameTP63 (603CT12.4.3) Monoclonal Antibody
Also known asTP63 (603CT12.4.3) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenTP63
SpecificityThis is a highly specific antibody against TP63.
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number603CT12.4.3
SourceThis TP63 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 651-680 amino acids from human TP63.
Gene ID number8626
Swiss ProtQ9H3D4
Tested ApplicationsWB
Recommended dilutionsWB(1:200~1600)
Cross reactivityHuman
Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the target antigenActs as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
Purification methodMouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Synonym namesAIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B); Tumor protein 63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like
PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
French translationanticorps