Caspase-9 (Thr125) Antibody

Catalog numberbs-3082R
NameCaspase-9 (Thr125) Antibody
Price€ 281.00
Size0.1ml
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Long nameCaspase-9 (Thr125) Primary Polyclonal Antibody
Also known asCaspase-9 (Thr125) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCaspase-9 Thr125
SpecificityThis is a highly specific antibody against Caspase-9 Thr125. This phosphorylation site is homologous to that of Thr163 in Mouse.
Modification(s)Phosphorylation
Modification site(s)Thr125
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range100-150/416
Subcellular locationCytoplasm, Nucleus, Mitochondrion
SourceKLH conjugated synthetic phosphopeptide derived from human Caspase-9 around the phosphorylation site of Thr125
Gene ID number842
Swiss ProtP55211
Tested ApplicationsWB, IHC-P, IF(IHC-P)
Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Cross reactivityHuman, Mouse
Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the target antigenInvolved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Purification methodThis antibody was purified via Protein A.
Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Synonym namesMCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; ICE-like apoptotic protease 6; CASP9
PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
DescriptionHuman and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
French translationanticorps