Rictor (Thr1135) Antibody, ALEXA FLUOR 594

Catalog numberbs-3387R-A594
NameRictor (Thr1135) Antibody, ALEXA FLUOR 594
Price€ 350.15
Size100ul
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Long nameRictor (Thr1135) Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
Also known asAnti-Rictor Thr1135 PAb ALEXA FLUOR 594
CategoryConjugated Primary Antibodies
Conjugated withALEXA FLUOR® 594
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenRictor Thr1135
SpecificityThis is a highly specific antibody against Rictor Thr1135.
ModificationPhosphorylation
Modification SiteThr1135
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range1100-1150/1732
Subcellular locationCytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human Rictor around the phosphorylation site of Thr1135
Gene ID Number253260
Swiss ProtQ6R327
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
CrossreactivityHuman, Mouse
Cross-reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigenSubunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
PurificationPurified by Protein A.
Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Excitation emission590nm/617nm
SynonymsPIA; AVO3; hAVO3; Rapamycin-insensitive companion of mTOR; AVO3 homolog; RICTOR; KIAA1999
PropertiesFor facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
ConjugationAlexa Fluor,ALEXA FLUOR® 594
ConjugatedAlexa conjugate 1
French translationanticorps