Frizzled 4/CD344 Antibody, ALEXA FLUOR 594

Catalog numberbs-13217R-A594
NameFrizzled 4/CD344 Antibody, ALEXA FLUOR 594
Price€ 332.75
Size100ul
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Long nameFrizzled 4/CD344 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
Also known asAnti-Frizzled 4/CD344 PAb ALEXA FLUOR 594
CategoryConjugated Primary Antibodies
Conjugated withALEXA FLUOR® 594
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenFrizzled 4/CD344
SpecificityThis is a highly specific antibody against Frizzled 4/CD344.
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range190-222/537
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Frizzled 4/CD344
Gene ID Number8322
Swiss ProtQ9ULV1
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
CrossreactivityHuman, Mouse, Rat
Cross-reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigenReceptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
PurificationPurified by Protein A.
Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Excitation emission590nm/617nm
SynonymsFz4; EVR1; FEVR; Fz-4; FzE4; GPCR; hFz4; CD344; FZD4S; Frizzled-4; FZD4
PropertiesFor facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
ConjugationAlexa Fluor,ALEXA FLUOR® 594
ConjugatedAlexa conjugate 1
French translationanticorps