Anti-EYA1 (Polyclonal), Cy7

Catalog numberGENTObs-20158R-Cy7
NameAnti-EYA1 (Polyclonal), Cy7
Price€ 516.00
Size100 microliters
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TypeConjugated Primary Antibody
Conjugated withCy7
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideEYA1
SpecificityThis antibody reacts specifically with EYA1 Cy7
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsCytoplasm, Nucleus
Antigen SourceKLH conjugated synthetic peptide derived from human EYA1
Gene ID2138
Swiss ProtQ99502
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive speciesHuman (Homo sapiens), Rat (Rattus norvegicus)
Cross Reactive Species detailsNo significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
Background informationFunctions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2.
Purification methodPurified by Protein A.
StorageWater buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Excitation emission743nm/767nm
SynonymsBOP; BOR; BOS1; OFC1; Eyes absent homolog 1; EYA1
Also known asEYA1 Polyclonal Antibody Cy7
Other nameAnti-EYA1 Polyclonal Cy7
AdvisoryAvoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.
ConjugationCy7
GroupPolyclonals and antibodies
AboutPolyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.